Endocrine Abstracts

Introduction: The aim of this study was to validate the American Thyroid Association (ATA) risk of recurrence staging system (2009).Methods: Retrospective analysed 300 adult (239 women, 61 men) differentiated thyroid cancer patients followed for a median of 57 months (range 38–97).Results: ATA risk stratification of patients according to the system 54.7% low-risk, 39.7% moderate risk, and 5.7% were in the high risk group. The ...

Colorectal cancer (CRC) is the third most common cancer worldwide with incidence expected to rise. Although not traditionally viewed as a hormonal cancer, evidence suggests peripheral synthesis of active oestrogens worsens prognosis. Oestrogen metabolising enzymes include steroid sulphatase (STS), which desulphates oestrogens into their active forms, and 17β-hydroxysteroid dehydrogenases (17βHSD), which are estrogen oxidoreductase enzymes. We have previously shown ST...

The calcium-sensing receptor (CaSR) is a guanine-nucleotide-binding protein (G-protein)-coupled receptor that has a central role in calcium homeostasis. Loss-of-function mutations of the CaSR result in familial hypocalciuric hypercalcemia type 1 (FHH1) and loss-of-function coding mutations in the CaSR-associated G-protein subunit Gα11 have been reported to cause FHH2 in only two patients to date. The aim of our study was therefore to characterise additional <em...

Pembrolizumab is a monoclonal antibody (ab) that exerts antineoplastic effects by inhibiting the immunoevasive effects PD-1 grants cancer cells. It’s used to treat several forms of cancer, including melanoma and non-small cell lung cancer. Despite the promise pembrolizumab has demonstrated, it has been associated with immune-related adverse events. In this report, we describe the first case of both thyroiditis and hypophysitis occurring during active pembrolizumab t...

Aim: Progesterone is thought to be associated with hyperemesis gravidarum (HG). Pregnancies in which progesterone is administered for luteal phase support do not exhibit an increased incidence of HG, suggesting that high progesterone levels alone do not cause HG. The aim of the present study was to evaluate the therapeutic role of progesterone therapy as a new modality in the management of hyperemesis.Subjects: In total, 40 Egyptian women below 40 years ...

Introduction: We report a patient with a solitary fibrous mesothelioma producing insulin -like growth factor (IGF) II who presented with recurrent episodes of early morning acute disorientation and agitation. .On examination he was noted to have decreased air entry at the right base and midzone and a mass in the right hypochondrium. . Radiologic imaging showed a large pleural based mass which almost completely filled the right hemithorax. When symptomatic hypoglycaemia was...

Introduction: The incidence of diabetes is increasing worldwide and type 2 diabetes in younger people is a growing phenomenon. From 1998 we have studied 21 subjects with early onset type 2 diabetes.Methods:11 subjects(7 males) with type 2 diabetes, age 23.7 plus/minus 1.01 years and 10 subjects(8 males) age 35.4 plus/minus 11.7 years were studied with an insulin modified (0.05 unit per kg ) intravenous glucose tolerance test. BMI was 34.3 plus/minus 1.4 kg per m2</sup...

Background and Aims:Over the next decade, the projected epidemic of Diabetes, their subsequent treatment requirements and complication management will emerge as a major threat to future public health. There are always demands for greater efficiency and cost-effectiveness within healthcare service especially in the bigger scale population study. Our aim is to develop a computerized system to facilitate diagnosis of Diabetes mellitus through co-ordination of multiple healthc...

A 58-year old previously independent man with background of poorly-controlled hypothyroidism, T2DM, hypertension, ischaemic cardiomyopathy, and CKD presented to hospital feeling generally unwell, with a dry cough. His regular medications included anti-hypertensives, L-thyroxine 50 μg daily, linagliptin, insulin, aspirin, atorvastatin, and thiamine. On admission, the TSH was 83 mIU/l, free T4 6.5 pmol/l and free T3 was 1.9 pmol/l; four months earlier, the TS...

Section 1: Case history: A 78 years old lady presented to Emergency Department with two weeks history of lethargy and confusion. She had background of advanced destructive Rheumatoid Arthritis diagnosed 30 years ago, multiple joint fractures, osteoporosis, long-term urinary catheter, recurrent UTI and renal calculi. She was recently discharged from hospital for urosepsis. She was bed-bound for the last 15 years after crushing vertebrae C2 C3 pressing on spinal cord. Her regula...